CENPC — Centromere protein C
CENPC belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CENPC's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | DNA damage response DNA/chromatin regulation | ATP2B1, DEAF1, FBXO34, HAX1, HECTD1, KMT5C, MRPL50, NDUFA5 +7 more | View in SCUBA |
| Gamma-delta T cells | Pre-mRNA Splicing RNA processing & translation | BCLAF1, CLK1, CNOT1, COG3, COPS2, DDX24, DDX3X, EPC1 +11 more | |
| Mucosal-associated invariant T cell | TCR Signal Attenuation Immune regulation | AFF4, BORCS5, CHD2, CRACR2A, CRYBG1, DUSP16, FAS, FNBP1 +8 more |
About the gene
| Synonyms | CENP-C, CENPC1, hcp-4, MIF2 |
|---|---|
| Chromosome | 4: 67468762-67545503 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Essential proteins, Predicted intracellular proteins |
| Molecular function | DNA-binding |
| Biological process | Cell cycle, Cell division, Mitosis |
Function
Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPC recruits DNA methylation and DNMT3B to both centromeric and pericentromeric satellite repeats and regulates the histone code in these regions.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.