FAS — Fas cell surface death receptor
FAS belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
FAS's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | B cell activation BCR/AP1/NFKb pathway | ADGRG5, BCAR3, CD86, CLIP2, CNOT2, CTSH, GABARAPL2, GPR137B +7 more | View in SCUBA |
| CD4⁺ T cells | Immune Regulation Immune regulation | ADAT2, AFTPH, C2CD4B, CDKL2, CPEB4, DDHD1, FAM53B, FNDC3B +10 more | View in SCUBA |
| Gamma-delta T cells | AHR/NF-κB Survival Immune regulation | ABCC1, AHR, ANKRD37, AREG, BAIAP2, BCL2L11, BEND4, BIRC3 +24 more | |
| Mucosal-associated invariant T cell | TCR Signal Attenuation Immune regulation | AFF4, BORCS5, CENPC, CHD2, CRACR2A, CRYBG1, DUSP16, FNBP1 +8 more |
About the gene
| Synonyms | APO-1, APT1, CD95, FAS1, TNFRSF6 |
|---|---|
| Chromosome | 10: 88953813-89029605 |
| Predicted location | Intracellular, Membrane, Secreted |
| Essential gene | No |
| Protein class | Cancer-related genes, Candidate cardiovascular disease genes, CD markers, Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins |
| Molecular function | Calmodulin-binding, Receptor |
| Biological process | Apoptosis |
Function
Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase CASP8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs CASP8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen- stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.