RNA Processing Housekeeping
Gene co-expression module in Macrophages
| Category | Housekeeping |
|---|---|
| Genes | 41 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 12 of 41 genes have a known function matching the annotation |
Why this annotation
Hub genes include SRSF11, SCAF11, DHX36, THOC2 (RNA splicing/export), NEMF (ribosome quality control), TNPO1 (nuclear import), BDP1 (RNA Pol III), CUL5 (ubiquitin ligase), DNM1L (mitochondrial fission), ROCK1 (cytoskeletal), GOLGA4 (Golgi). This is a mixed module of RNA processing, nuclear transport, and general cellular maintenance. Weak coherence and uniform expression across all subsets indicate broad housekeeping co-variation. Neighbor context with M85 (chromatin) and M5 (splicing) confirms a housekeeping RNA/protein biogenesis theme.
Genes
BAZ1A, BDP1, CCAR1, CCDC88A, CLIP1, CUL5, DHX36, DNM1L, EP400, GOLGA4, ICE1, LARP4, LTN1, MGA, MTF2, NCOR1, NEMF, NSD3, PBRM1, PCM1, PPHLN1, PPP1R12A, PRRC2C, ROCK1, SAFB, SBNO1, SCAF11, SLTM, SMAD2, SRSF11, STAT3, TCERG1, THOC2, TNPO1, UBAP2L, UBE4A, USP7, USP8, ZC3H18, ZNF800, ZRANB2
Most correlated modules
- Chromatin Regulatory Genes · correlation 0.97
- mRNA Splicing Processing · correlation 0.96
- ER-Golgi Trafficking · correlation 0.95
- Endolysosomal Trafficking · correlation 0.95
- RNA Processing Transport · correlation 0.95
- Microtubule Organization · correlation 0.95
- Transcriptional Repression · correlation 0.95
- General Cellular Maintenance · correlation 0.95
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.