Hypoxia Response
Gene co-expression module in Natural Killer cells
| Category | Stress |
|---|---|
| Genes | 11 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 11 genes have a known function matching the annotation |
Why this annotation
EPAS1 (HIF-2alpha) is a canonical hypoxia-inducible factor driving adaptation to low oxygen, relevant in inflamed intestinal tissue. SPRY1 is a negative feedback regulator of RTK/MAPK signaling induced under stress/hypoxia. RGS1 marks recently activated or tissue-resident lymphocytes and is upregulated under hypoxic/inflammatory conditions. LPIN1 links to lipid remodeling under metabolic stress. MAML3 (Notch co-activator) and RHOQ (Rho GTPase) may reflect downstream hypoxia-driven transcriptional and cytoskeletal responses. The module is upregulated in UC and CD inflammation, consistent with a hypoxia/tissue-stress response in the inflamed intestinal microenvironment.
Genes
ANKRD28, ATP8B4, EPAS1, HIP1, LPIN1, MAML3, MDFIC, RGS1, RHOQ, SPRY1, ZNF609
Most correlated modules
- NK Tissue Residency · correlation 0.84
- Mature NK Identity · correlation 0.82
- Resident NK program · correlation 0.81
- NK Cytoskeletal Activation · correlation 0.81
- NK Checkpoint Receptors · correlation 0.77
- Gut-Homing NK · correlation 0.73
- Tissue-Resident NK · correlation 0.71
- NK Inflammatory Activation · correlation 0.70
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.