LPIN1 — Lipin 1
LPIN1 belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
LPIN1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Chromatin modifiers DNA/chromatin regulation | ATP2A3, BIRC6, KDM5A, KMT2C, MBNL1, NCOA3, NFAT5, RBM5 +1 more | View in SCUBA |
| CD4⁺ T cells | Immune regulation Immune regulation | DENND1B, FAM111A, GIT2, GOLGA8A, NLRC3, PPP2R5C, PSD4, RUFY3 +5 more | View in SCUBA |
| Gamma-delta T cells | Activation Stress Response Stress | ARHGAP9, ARHGEF12, ATF3, ATP6V0A2, GALNT6, GPR18, HIC1, HMCES +12 more | |
| Hematopoietic progenitor cells | HOX HSC Program Stemness | ADGRE2, AFF1, ARHGAP25, HOXA3, HOXA6, HOXA9, JAML, MOB1B +3 more | |
| Innate lymphoid cells | NK ILC Tissue Homing Homing & TEM | ADGRE5, AKAP13, AREG, ARL4C, ATP1B3, B3GNT7, BTG1, CCDC107 +25 more | View in SCUBA |
| Mucosal-associated invariant T cell | Tissue Residency Regulation Tissue residence | ABCC1, ANKRD28, ARHGEF7, CA2, CDV3, CHD7, CYTIP, IL18R1 +4 more | |
| Natural Killer cells | Hypoxia Response Stress | ANKRD28, ATP8B4, EPAS1, HIP1, MAML3, MDFIC, RGS1, RHOQ +2 more | View in SCUBA |
About the gene
| Synonyms | KIAA0188 |
|---|---|
| Chromosome | 2: 11677595-11827409 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins |
| Molecular function | Hydrolase |
| Biological process | Fatty acid metabolism, Lipid metabolism, Transcription, Transcription regulation |
Function
Acts as a magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis and therefore controls the metabolism of fatty acids at different levels. Is involved in adipocyte differentiation (By similarity). Recruited at the mitochondrion outer membrane and is involved in mitochondrial fission by converting phosphatidic acid to diacylglycerol (By similarity). Acts also as nuclear transcriptional coactivator for PPARGC1A/PPARA regulatory pathway to modulate lipid metabolism gene expression (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.