RHOQ — Ras homolog family member Q
RHOQ belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
RHOQ's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | B-cell activation B cell maturation | ADAM19, ARHGAP30, CD164, CD19, CD47, CLN8, CPEB4, ELK3 +15 more | View in SCUBA |
| Gamma-delta T cells | Hypoxia Tissue Adaptation Tissue residence | ABCB1, ADAMTS17, ANKRD28, CCRL2, EPAS1, FAM3C, KLHL6, LDLRAD4 +10 more | |
| Macrophages | ER-Golgi Trafficking Vesicular traficking | ADD1, AFTPH, AZIN1, COPA, DYNC1H1, HNRNPC, JOSD1, LCP2 +23 more | View in SCUBA |
| Natural Killer cells | Hypoxia Response Stress | ANKRD28, ATP8B4, EPAS1, HIP1, LPIN1, MAML3, MDFIC, RGS1 +2 more | View in SCUBA |
| Pericytes | Pericyte Inflammatory Activation Inflammatory | BATF3, CRISPLD2, FILIP1L, KCNJ8, MARCKS, PAG1, PDGFA, RHOBTB3 +3 more | View in SCUBA |
About the gene
| Synonyms | ARHQ, RASL7A, TC10 |
|---|---|
| Chromosome | 2: 46541806-46584688 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Essential proteins, Predicted intracellular proteins |
Function
Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. May play a role in CFTR trafficking to the plasma membrane. Causes the formation of thin, actin-rich surface projections called filopodia
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.