MATR3 — Matrin 3
MATR3 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
MATR3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | RNA Splicing Nuclear RNA processing & translation | ATRAID, BABAM2, C7orf50, CIB1, CSNK2A1, FUNDC2, GOLGA8A, GOLGA8B +10 more | |
| Macrophages | Resident Mac Niche Tissue homeostasis | AGGF1, ALDH1A1, ARL5A, CD163L1, CD209, CHN2, CLEC4F, CLIC2 +22 more | View in SCUBA |
| Mucosal-associated invariant T cell | RNA Splicing m6A RNA processing & translation | ARF1, ARF6, ATP5F1B, CIRBP, CORO7, EIF1B, EIF5A, EMD +15 more |
About the gene
| Synonyms | KIAA0723, MGC9105, MPD2, VCPDM |
|---|---|
| Chromosome | 5: 139293674-139331677 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins |
| Molecular function | RNA-binding |
| Biological process | Immunity, Innate immunity |
Function
May play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network. In association with the SFPQ-NONO heteromer may play a role in nuclear retention of defective RNAs. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway. Binds to N6-methyladenosine (m6A)-containing mRNAs and contributes to MYC stability by binding to m6A-containing MYC mRNAs. May bind to specific miRNA hairpins.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.