MECOM — MDS1 and EVI1 complex locus
MECOM belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
MECOM's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | EC Inflammatory Activation Inflammation | ARHGAP4, ARHGEF2, ARL15, ATP13A3, CAPZA2, CD58, GFOD1, GJA4 +12 more | View in SCUBA |
| Enterocytes | Long-gene intronic signal Technical artifact | ASCC3, CASK, KCNQ1, LGR4, MAP3K5, MID1, PPP1R9A, RALGAPA2 +5 more | View in SCUBA |
| Pericytes | Arterial Identity TFs Developmental | EPHA4, FLNB, GATA2, MAST4, MTUS1, PALMD, PIK3C2B, SOX17 | View in SCUBA |
About the gene
| Synonyms | EVI1, KMT8E, MDS1, MDS1-EVI1, PRDM3 |
|---|---|
| Chromosome | 3: 169083499-169663775 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Transcription factors |
| Molecular function | Developmental protein, DNA-binding, Methyltransferase, Transferase |
| Biological process | Apoptosis, Differentiation, Transcription, Transcription regulation |
Function
Functions as a transcriptional regulator binding to DNA sequences in the promoter region of target genes and regulating positively or negatively their expression. Oncogene which plays a role in development, cell proliferation and differentiation. May also play a role in apoptosis through regulation of the JNK and TGF-beta signaling. Involved in hematopoiesis. Displays histone methyltransferase activity and monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro. Probably catalyzes the monomethylation of free histone H3 in the cytoplasm which is then transported to the nucleus and incorporated into nucleosomes where SUV39H methyltransferases use it as a substrate to catalyze histone H3 'Lys-9' trimethylation. Likely to be one of the primary histone methyltransferases along with PRDM16 that direct cytoplasmic H3K9me1 methylation
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.