PIK3C2B — Phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta
PIK3C2B belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PIK3C2B's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | BCR signaling/maturation B cell maturation | ATP6V0A1, BCL11A, CAMK2D, CD22, CLEC2D, DDHD1, DGKD, IL4R +9 more | View in SCUBA |
| Endothelial | Inflammatory Angiogenesis Inflammation | AZIN1, DHH, FBLN5, FILIP1L, GJA5, ITSN2, NUDT4, OCIAD2 +6 more | View in SCUBA |
| Lymphatic endothelial | Actin Cytoskeletal Dynamics Cytoskeletal | ACTN1, BMAL2, NAV2, PFKP, PRRC2C, SLC39A14, SYNJ2 | View in SCUBA |
| Pericytes | Arterial Identity TFs Developmental | EPHA4, FLNB, GATA2, MAST4, MECOM, MTUS1, PALMD, SOX17 | View in SCUBA |
About the gene
| Synonyms | C2-PI3K, PI3K-C2beta |
|---|---|
| Chromosome | 1: 204422628-204494805 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Kinase, Transferase |
| Biological process | Lipid metabolism |
Function
Phosphorylates PtdIns and PtdIns4P with a preference for PtdIns. Does not phosphorylate PtdIns(4,5)P2. May be involved in EGF and PDGF signaling cascades.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.