MTUS1 — Microtubule associated scaffold protein 1
MTUS1 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
MTUS1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Tfh program B cell help | BAZ2B, CCDC50, CDK5R1, CXCR5, IL6R, LY96, PASK, PIP4P2 +10 more | View in SCUBA |
| Enterocytes | Mature colonocyte metabolism Nutrient metabolism | ANXA4, ASS1, ATP1B3, BTNL3, CORO2A, HMCN2, MGAT4A, MOB3B +6 more | View in SCUBA |
| Lymphatic endothelial | Lymphatic Specification endothelial development | ARHGAP29, BOD1L1, CALD1, CLCN3, DECR1, GCC2, MINDY2, MPHOSPH8 +9 more | View in SCUBA |
| Pericytes | Arterial Identity TFs Developmental | EPHA4, FLNB, GATA2, MAST4, MECOM, PALMD, PIK3C2B, SOX17 | View in SCUBA |
About the gene
| Synonyms | ATBP, ATIP1, ATIP3, DKFZp586D1519, FLJ14295, ICIS, KIAA1288, MP44, MTSG1 |
|---|---|
| Chromosome | 8: 17643795-17801094 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Disease related genes, Predicted intracellular proteins, Predicted membrane proteins |
Function
Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation. Isoform 1 inhibits breast cancer cell proliferation, delays the progression of mitosis by prolonging metaphase and reduces tumor growth.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.