Inflammatory Endothelial Activation
Gene co-expression module in Endothelial
| Category | Inflammation |
|---|---|
| Genes | 17 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 11 of 17 genes have a known function matching the annotation |
Why this annotation
F2R (PAR1/thrombin receptor) is a key endothelial inflammatory mediator activated by coagulation proteases during intestinal inflammation. FKBP10 supports collagen folding in ER. FSTL1 and TWSG1 are BMP pathway modulators expressed in activated endothelium. ROBO1 regulates angiogenic sprouting. SVIL, RAI14, COTL1 are actin-cytoskeletal remodeling genes. JAK1 mediates cytokine signaling. DEGS1 is involved in ceramide/sphingolipid metabolism relevant to endothelial activation. Strong inflammation delta (0.54 UC) with remission reversal supports active inflammatory endothelial state. The BMP antagonism (TWSG1, FSTL1) and cytoskeletal remodeling suggest endothelial activation with barrier remodeling.
Genes
ANXA6, CNIH1, COTL1, DEGS1, DHRS7, F2R, FKBP10, FSTL1, JAK1, MEOX1, NR5A2, PRDX6, RAI14, ROBO1, RRBP1, SVIL, TWSG1
Most correlated modules
- Hypoxia Response · correlation 0.90
- NF-κB Oxidative Stress · correlation 0.89
- Lysosomal Autophagy Program · correlation 0.86
- Wnt Angiogenic Remodeling · correlation 0.85
- ER Protein Processing · correlation 0.85
- p53 Stress Response · correlation 0.84
- Procoagulant TGF-β Response · correlation 0.83
- Spliceosome snRNP Assembly · correlation 0.77
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.