MKLN1 — Muskelin 1
MKLN1 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
MKLN1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Lymphatic endothelial | ZEB1-driven EMT endothelial development | ASH1L, CUX1, ERBIN, ITSN2, KIF1B, NFAT5, NIPBL, PAFAH1B1 +7 more | View in SCUBA |
| Macrophages | Rho GTPase Signaling Cytoskeletal | ABCC1, ABR, ANKRD17, ARFGEF2, ARHGAP10, ARID2, ATAD2B, ATP9B +44 more | View in SCUBA |
| Neutrophils | Actin Cytoskeletal Remodeling Cytoskeletal | ACAP2, ARHGAP15, COP1, CUX1, DOCK8, DPYD, KDM2A, MED13L +9 more |
About the gene
| Synonyms | TWA2 |
|---|---|
| Chromosome | 7: 131110096-131496632 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
Function
Component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. Required for internalization of the GABA receptor GABRA1 from the cell membrane via endosomes and subsequent GABRA1 degradation (By similarity). Acts as a mediator of cell spreading and cytoskeletal responses to the extracellular matrix component THBS1.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.