KIF1B — Kinesin family member 1B
KIF1B belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
KIF1B's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Effector Cytokine Secretion Inflammation | APBA2, ASPH, CCL3, CCL4, CMC1, CYRIA, DTHD1, DTNBP1 +25 more | |
| Lymphatic endothelial | ZEB1-driven EMT endothelial development | ASH1L, CUX1, ERBIN, ITSN2, MKLN1, NFAT5, NIPBL, PAFAH1B1 +7 more | View in SCUBA |
| Macrophages | Chromatin Epigenetic Regulation Housekeeping | ABHD17B, ANKH, ARHGAP21, CCNH, CTTNBP2NL, DMXL1, EEIG2, ELF2 +21 more | View in SCUBA |
About the gene
| Synonyms | CMT2, CMT2A, HMSNII, KIAA0591, KLP |
|---|---|
| Chromosome | 1: 10210570-10381603 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Isomerase, Motor protein |
| Biological process | Apoptosis |
Function
Has a plus-end-directed microtubule motor activity and functions as a motor for transport of vesicles and organelles along microtubules. Has a plus-end-directed microtubule motor activity and functions as a motor for anterograde synaptic vesicle transport along axonal microtubules from the cell body to the presynapse in neuronal cells (By similarity). Functions as a downstream effector in a developmental apoptotic pathway that is activated when nerve growth factor (NGF) becomes limiting for neuronal progenitor cells. Has a plus-end-directed microtubule motor activity and functions as a motor for anterograde transport of mitochondria
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.