ZEB1-driven EMT
Gene co-expression module in Lymphatic endothelial
| Category | endothelial development |
|---|---|
| Genes | 16 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 10 of 16 genes have a known function matching the annotation |
Why this annotation
ZEB1 is a canonical EMT transcription factor and key regulator of lymphatic endothelial identity and lymphangiogenesis. NIPBL (cohesin loader), ASH1L, WAC, SETD5 (histone methyltransferases) are chromatin regulators that co-regulate developmental gene programs. PAFAH1B1 (LIS1) regulates microtubule dynamics. NFAT5 responds to osmotic/inflammatory stress. QKI is an RNA-binding protein important in vascular development. RORA is a nuclear receptor with roles in circadian/inflammatory regulation. The significant upregulation in CD inflammation (delta_inflammation_CD sig.) supports an inflammation-responsive LEC identity/EMT program. Neighbor context: shares chromatin regulatory genes with M90, but ZEB1 and NFAT5 add an EMT/inflammatory dimension.
Genes
ASH1L, CUX1, ERBIN, ITSN2, KIF1B, MKLN1, NFAT5, NIPBL, PAFAH1B1, QKI, RORA, SETD5, SIK2, UBR5, WAC, ZEB1
Most correlated modules
- Chromatin Remodeling · correlation 0.96
- MAPK-ERK Signaling · correlation 0.95
- Hippo-Adhesion Signaling · correlation 0.90
- ECM-driven Migration · correlation 0.89
- Actin-based Migration · correlation 0.89
- NF-κB Innate Signaling · correlation 0.88
- Focal Adhesion Migration · correlation 0.86
- Rho/Ras GTPase Regulation · correlation 0.86
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.