Arterial EC Identity
Gene co-expression module in Endothelial
| Category | Endothelial cell development |
|---|---|
| Genes | 10 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 10 genes have a known function matching the annotation |
Why this annotation
HHEX is a homeobox TF critical for arterial/portal venous EC identity and liver/gut vascular development. CLDN5 encodes claudin-5, a tight junction protein marking barrier-forming ECs (arterial/capillary). PERP is a p53 target involved in apoptosis. AGPAT2 is involved in phospholipid/lipid metabolism. LY6E is interferon-stimulated. ADAM23 is a disintegrin metalloprotease. The combination of HHEX+CLDN5 strongly suggests an arterial or capillary EC identity with barrier properties. Modest changes in both UC and CD inflammation. Neighbor context (near venular modules M41/M76) suggests this represents a complementary arterial/capillary EC identity program.
Genes
ADAM23, AGPAT2, CLDN5, ECHDC2, GOLGA8B, HHEX, LY6E, NDN, PERP, TPBG
Most correlated modules
- IL33 Alarmin Signaling · correlation 0.88
- Venous EC Identity · correlation 0.85
- Macrophage Contamination · correlation 0.85
- Hypoxia Stress Response · correlation 0.81
- Venular Inflammatory Activation · correlation 0.81
- Angiogenic Metabolic Adaptation · correlation 0.77
- Inflammatory Stress Response · correlation 0.75
- Leukocyte Recruitment Signaling · correlation 0.75
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.