NFIC — Nuclear factor I C
NFIC belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
NFIC's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Lymphatic endothelial | Lymphatic Specification endothelial development | ARHGAP29, BOD1L1, CALD1, CLCN3, DECR1, GCC2, MINDY2, MPHOSPH8 +9 more | View in SCUBA |
| Macrophages | TGF-beta Signaling Inflammatory | APPL1, BBX, C6orf89, CCDC50, CREB3L2, HCLS1, NCKAP1L, POGK +9 more | View in SCUBA |
About the gene
| Synonyms | CTF, CTF5, NF-I, NFI |
|---|---|
| Chromosome | 19: 3314403-3469217 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins, Transcription factors |
| Molecular function | Activator, DNA-binding |
| Biological process | DNA replication, Transcription, Transcription regulation |
Function
Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.