NCKAP1L — NCK associated protein 1 like
NCKAP1L belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
NCKAP1L's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Actomyosin signaling migration & adhesion | ACIN1, CYBC1, EIF4G3, GALNT1, HNRNPA3, PPP1R12A, PRKCH, PTPRA +8 more | View in SCUBA |
| Gamma-delta T cells | Butyrophilin gd Activation TCR Signaling | ABI1, ADD3, ANXA6, ARHGAP1, ARHGAP25, ARHGAP30, ARHGEF2, BTN3A1 +16 more | |
| Macrophages | TGF-beta Signaling Inflammatory | APPL1, BBX, C6orf89, CCDC50, CREB3L2, HCLS1, NFIC, POGK +9 more | View in SCUBA |
| Mucosal-associated invariant T cell | Chromatin Complex Regulation DNA/chromatin regulation | APEH, CAPZB, CCND2, CFH, CHTF8, ESYT1, GDI2, HACD4 +9 more |
About the gene
| Synonyms | HEM1 |
|---|---|
| Chromosome | 12: 54497752-54548243 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Plasma proteins, Predicted membrane proteins |
Function
Essential hematopoietic-specific regulator of the actin cytoskeleton (Probable). Controls lymphocyte development, activation, proliferation and homeostasis, erythrocyte membrane stability, as well as phagocytosis and migration by neutrophils and macrophages. Component of the WAVE2 complex which signals downstream of RAC to stimulate F-actin polymerization. Required for stabilization and/or translation of the WAVE2 complex proteins in hematopoietic cells (By similarity). Within the WAVE2 complex, enables the cortical actin network to restrain excessive degranulation and granule release by T-cells. Required for efficient T-lymphocyte and neutrophil migration. Exhibits complex cycles of activation and inhibition to generate waves of propagating the assembly with actin. Also involved in mechanisms WAVE-independent to regulate myosin and actin polymerization during neutrophil chemotaxis. In T-cells, required for proper mechanistic target of rapamycin complex 2 (mTORC2)-dependent AKT phosphorylation, cell proliferation and cytokine secretion, including that of IL2 and TNF.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.