APPL1 — Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1
APPL1 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
APPL1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | DNA Damage Repair DNA/chromatin regulation | GPAA1, HMGB1, HNRNPM, HNRNPR, NAP1L4, NCL, PRDX3, PRKDC +7 more | View in SCUBA |
| Innate lymphoid cells | Centrosome & Scaffolding Cytoskeleton & motility | AKAP9, ARID4A, CCDC91, CPNE3, ETNK1, FAM204A, GOPC, LRBA +14 more | View in SCUBA |
| Macrophages | TGF-beta Signaling Inflammatory | BBX, C6orf89, CCDC50, CREB3L2, HCLS1, NCKAP1L, NFIC, POGK +9 more | View in SCUBA |
About the gene
| Synonyms | APPL |
|---|---|
| Chromosome | 3: 57227726-57278105 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Predicted intracellular proteins |
| Biological process | Cell cycle |
Function
Multifunctional adapter protein that binds to various membrane receptors, nuclear factors and signaling proteins to regulate many processes, such as cell proliferation, immune response, endosomal trafficking and cell metabolism. Regulates signaling pathway leading to cell proliferation through interaction with RAB5A and subunits of the NuRD/MeCP1 complex. Functions as a positive regulator of innate immune response via activation of AKT1 signaling pathway by forming a complex with APPL1 and PIK3R1 (By similarity). Inhibits Fc-gamma receptor-mediated phagocytosis through PI3K/Akt signaling in macrophages (By similarity). Regulates TLR4 signaling in activated macrophages (By similarity). Involved in trafficking of the TGFBR1 from the endosomes to the nucleus via microtubules in a TRAF6-dependent manner. Plays a role in cell metabolism by regulating adiponecting and insulin signaling pathways. Required for fibroblast migration through HGF cell signaling (By similarity). Positive regulator of beta-catenin/TCF-dependent transcription through direct interaction with RUVBL2/reptin resulting in the relief of RUVBL2-mediated repression of beta-catenin/TCF target genes by modulating the interactions within the beta-catenin-reptin- HDAC complex.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.