TGF-beta Signaling
Gene co-expression module in Macrophages
| Category | Inflammatory |
|---|---|
| Genes | 18 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 7 of 18 genes have a known function matching the annotation |
Why this annotation
CREB3L2 is a UPR/ER stress transcription factor; UGGT1 is an ER quality control glucosyltransferase; TGFBR1 mediates TGF-β signaling; NCKAP1L is a macrophage-enriched actin regulatory subunit; APPL1 is an endosomal signaling adaptor; UPF1 mediates nonsense-mediated mRNA decay; SACM1L is a PI4P phosphatase at the Golgi/ER. The module is weakly coherent and mixes ER stress, TGF-β, and mRNA surveillance programs. The dominant signal among hub genes points to TGF-β/ER stress regulatory crosstalk.
Genes
APPL1, BBX, C6orf89, CCDC50, CREB3L2, HCLS1, NCKAP1L, NFIC, POGK, RHOBTB3, SACM1L, SLC38A10, STARD7, TGFBR1, UGGT1, UPF1, USP22, ZNF330
Most correlated modules
- Myeloid Innate Signaling · correlation 0.97
- Chromatin Transcriptional Regulation · correlation 0.96
- Retromer Endosomal Sorting · correlation 0.96
- Autophagy Vesicular Trafficking · correlation 0.95
- General Cellular Maintenance · correlation 0.95
- ER Protein Quality Control · correlation 0.94
- Endosomal Membrane Trafficking · correlation 0.94
- Myeloid Differentiation Identity · correlation 0.93
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.