NGEF — Neuronal guanine nucleotide exchange factor
NGEF belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
NGEF's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Enterocytes | Mature colonocyte brush-border Epithelial development | AGMO, ATP8A1, CA3, CNKSR3, COBL, EMB, EPB41L3, PAG1 +2 more | View in SCUBA |
About the gene
| Synonyms | ARHGEF27 |
|---|---|
| Chromosome | 2: 232878701-233013256 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | Developmental protein, Guanine-nucleotide releasing factor |
| Biological process | Differentiation, Neurogenesis |
Function
Acts as a guanine nucleotide exchange factor (GEF) which differentially activates the GTPases RHOA, RAC1 and CDC42. Plays a role in axon guidance regulating ephrin-induced growth cone collapse and dendritic spine morphogenesis. Upon activation by ephrin through EPHA4, the GEF activity switches toward RHOA resulting in its activation. Activated RHOA promotes cone retraction at the expense of RAC1- and CDC42-stimulated growth cone extension (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.