Mature colonocyte brush-border
Gene co-expression module in Enterocytes
| Category | Epithelial development |
|---|---|
| Genes | 11 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 7 of 11 genes have a known function matching the annotation |
Why this annotation
CA3, AGMO (alkylglycerol monooxygenase), COBL (cordon-bleu, which drives microvillus/brush-border actin assembly), EPB41L3, NGEF and ATP8A1 (a flippase) suggest a mature colonocyte program. It combines apical membrane organization with metabolism and resembles distal colonocyte maturation markers. Its co-expression with the other absorptive modules supports a shared mature-enterocyte state.
Genes
AGMO, ATP8A1, CA3, CNKSR3, COBL, EMB, EPB41L3, NGEF, PAG1, TINAG, ZZEF1
Most correlated modules
- Colonocyte differentiation signaling · correlation 0.87
- Sterol Transfer · correlation 0.87
- Chylomicron lipid absorption · correlation 0.85
- Enterocyte fatty-acid catabolism · correlation 0.84
- Brush-border nutrient uptake · correlation 0.83
- Enterocyte lipid trafficking · correlation 0.83
- Colonocyte Solute Transport · correlation 0.83
- PPARA/FXR fatty acid oxidation · correlation 0.78
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.