NMT2 — N-myristoyltransferase 2
NMT2 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
NMT2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Post-transcriptional regulation RNA processing | BCL11B, CCDC14, CHD2, CHD6, CREBZF, DDX39B, DNASE1, EVI2B +21 more | View in SCUBA |
| Hematopoietic progenitor cells | Mast Cell Differentiation Granulocyte development | ACSL4, ALOX5AP, BACE2, CDK15, CNKSR3, FAM81B, FAM83F, FOXJ1 +6 more | |
| Innate lymphoid cells | Transcriptional Regulation DNA regulation & transcription | ACAA1, ATRX, C1orf43, CARHSP1, CHTOP, CTDSP1, CTR9, DRAP1 +18 more | View in SCUBA |
About the gene
| Chromosome | 10: 15102584-15168693 |
|---|---|
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Predicted intracellular proteins |
| Molecular function | Acyltransferase, Transferase |
Function
Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins. Also able to mediate N-terminal lysine myristoylation of proteins: catalyzes myristoylation of ARF6 on both 'Gly-2' and 'Lys-3'. Lysine myristoylation is required to maintain ARF6 on membranes during the GTPase cycle.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.