PGD — Phosphogluconate dehydrogenase
PGD belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PGD's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Macrophages | Osmotic Stress Response Stress | ANKRD28, BZW1, CD109, CXCL8, CYB5R4, CYTIP, DUSP4, EMP3 +25 more | View in SCUBA |
| Monocytes | Pentose Phosphate Pathway Innate immunity | ACAP1, AP5B1, CCDC69, CCND3, CITED4, CORO2A, DYSF, EIF4E3 +4 more | View in SCUBA |
| Neutrophils | Pentose Phosphate Pathway Housekeeping | ANXA3, ARPC2, CAP1, CDA, GYG1, HMGB2, LBR, SNX3 +1 more |
About the gene
| Chromosome | 1: 10398592-10420511 |
|---|---|
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Enzymes, Essential proteins, Metabolic proteins, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Oxidoreductase |
| Biological process | Gluconate utilization, Pentose shunt |
Function
Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.