PHACTR1 — Phosphatase and actin regulator 1
PHACTR1 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PHACTR1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | NF-kB activation/survival BCR/AP1/NFKb pathway | ARL4C, BCL2A1, CCR7, DDX21, GNG2, ICAM1, IRF2BPL, LMNA +9 more | View in SCUBA |
| Macrophages | Transcriptional Regulation Housekeeping | AATF, ABHD5, ARID3B, DCP1A, GGNBP2, MIA2, MSI2, NR2C2 +18 more | View in SCUBA |
| Monocytes | Epigenetic Inflammatory Reprogramming Inflammatory | BHLHE40, EHD1, KDM6B, PLEK, PPIF, SMAD7, SOD2, ZNF267 | View in SCUBA |
| Neutrophils | Chemokine Secretion Cytokine & chemokine secretion | CXCL1, CXCL2, CXCL8, DDIT3, GADD45B, GLUL, HCAR2, IER5 +3 more |
About the gene
| Synonyms | dJ257A7.2, KIAA1733, RPEL1 |
|---|---|
| Chromosome | 6: 12716312-13290446 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Actin-binding, Protein phosphatase inhibitor |
Function
Binds actin monomers (G actin) and plays a role in multiple processes including the regulation of actin cytoskeleton dynamics, actin stress fibers formation, cell motility and survival, formation of tubules by endothelial cells, and regulation of PPP1CA activity. Involved in the regulation of cortical neuron migration and dendrite arborization (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.