NF-kB activation/survival
Gene co-expression module in CD19⁺ B cells
| Category | BCR/AP1/NFKb pathway |
|---|---|
| Genes | 18 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 18 genes have a known function matching the annotation |
Why this annotation
Hub genes include PIM3 (kinase), NFE2L2 (NRF2 oxidative stress TF), CCR7 (lymphocyte homing), ICAM1 (adhesion), NAMPT, BCL2A1 (NFKB-induced anti-apoptotic), SERPINB9, and IRF2BPL. This is an activation/survival program with NFKB target genes (BCL2A1, ICAM1, NAMPT, SERPINB9) and adhesion/migration components (CCR7, ICAM1, ARL4C, LMNA). The blend of NFKB-induced survival genes and activation markers points to an NFKB-driven B-cell activation/survival state. Core coherence, uniform expression, neighbor of NFKB modules M87/M9.
Genes
ARL4C, BCL2A1, CCR7, DDX21, GNG2, ICAM1, IRF2BPL, LMNA, NAMPT, NFE2L2, PHACTR1, PIM3, RAB8B, RARA, SDCBP, SERPINB9, SNX9, UBALD2
Most correlated modules
- TNF/NF-kB response · correlation 0.85
- NF-kB signaling · correlation 0.84
- Immediate early response · correlation 0.81
- Oxidative/ER stress · correlation 0.76
- Activation/Migration · correlation 0.76
- Immediate Early NFkB · correlation 0.69
- Plasma cell secretory · correlation 0.69
- NFkB/MAPK activation · correlation 0.67
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.