PI3 — Peptidase inhibitor 3
PI3 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PI3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Goblet cells | Mucosal Antibacterial Defense Immune function | ANXA11, B3GNT7, C15orf48, C19orf33, CLIC1, CSTB, CYSTM1, ELOB +8 more | View in SCUBA |
| Neutrophils | CC Chemokine Secretion Cytokine & chemokine secretion | C15orf48, CCL20, CCL3, CCL3L3, CCL4, CCL4L2, CCRL2, CD83 +4 more |
About the gene
| Synonyms | cementoin, ELAFIN, ESI, SKALP, WAP3, WFDC14 |
|---|---|
| Chromosome | 20: 45174902-45176544 |
| Predicted location | Secreted |
| Essential gene | No |
| Protein class | Plasma proteins, Predicted secreted proteins |
| Molecular function | Protease inhibitor, Serine protease inhibitor |
Function
Neutrophil and pancreatic elastase-specific inhibitor of skin. It may prevent elastase-mediated tissue proteolysis. Has been shown to inhibit the alpha-4-beta-2/CHRNA2-CHRNB2 nicotinic acetylcholine receptor and to produce a weak inhibition on Kv11.1/KCNH2/ERG1 and on the transient receptor potential cation channel subfamily V member 1 (TRPV1)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.