PPIP5K2 — Diphosphoinositol pentakisphosphate kinase 2
PPIP5K2 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PPIP5K2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Macrophages | Chromatin Transcriptional Regulation Housekeeping | AGO1, ARID1A, CARD8, CEPT1, CLOCK, CPSF7, CTNND1, DCAF10 +19 more | View in SCUBA |
| Mucosal-associated invariant T cell | Nuclear regulatory housekeeping Housekeeping | ATXN2, BAZ1B, CCDC90B, CD164, CREB1, GIGYF2, HELB, HNRNPA2B1 +6 more |
About the gene
| Synonyms | CFAP160, DFNB100, HISPPD1, KIAA0433, VIP2 |
|---|---|
| Chromosome | 5: 103120149-103212799 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins |
| Molecular function | Kinase, Transferase |
| Biological process | Hearing |
Function
Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation. Phosphorylates inositol hexakisphosphate (InsP6) at position 1 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4. Alternatively, phosphorylates PP-InsP5 at position 1, produced by IP6Ks from InsP6, to produce (PP)2-InsP4. Required for normal hearing.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.