PTPRO — Protein tyrosine phosphatase receptor type O
PTPRO belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PTPRO's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Goblet cells | Mature Colonocyte Function Epithelial development | ADD3, CERS6, CFTR, GAS6, LEFTY1, MAOA, NOX1, PDCD4 +2 more | View in SCUBA |
| Macrophages | Monocyte Phagocytic Identity Lysosomal & pahgocytosis | CD14, CD99, CMTM3, DUSP3, FCGR2A, FLOT2, INF2, MARVELD1 +7 more | View in SCUBA |
About the gene
| Synonyms | GLEPP1, NPHS6, PTP-oc, PTP-U2, PTPU2 |
|---|---|
| Chromosome | 12: 15322257-15602175 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Hydrolase, Protein phosphatase, Receptor |
Function
Possesses tyrosine phosphatase activity. Plays a role in regulating the glomerular pressure/filtration rate relationship through an effect on podocyte structure and function (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.