CERS6 — Ceramide synthase 6
CERS6 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CERS6's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Enterocytes | Long-gene nuclear transcripts Technical artifact | ARL15, BLNK, EXT1, FHIT, FUT8, KANK1, LDLRAD4, LRBA +6 more | View in SCUBA |
| Goblet cells | Mature Colonocyte Function Epithelial development | ADD3, CFTR, GAS6, LEFTY1, MAOA, NOX1, PDCD4, PLBD1 +2 more | View in SCUBA |
| Lymphatic endothelial | Lymphatic EC Identity Gut residence | CD36, CHST15, DOCK5, EPS15, FRMD4B, FRY, IL7, ITSN1 +4 more | View in SCUBA |
| Macrophages | MITF Lysosomal Program Lysosomal & pahgocytosis | ABHD3, ANKRD44, ARSB, C2CD5, CHST11, CNST, DCTN4, FBXL20 +25 more | View in SCUBA |
| Neutrophils | Myeloid Maturation Developmental | AFF2, DGKG, FAF1, LRMDA, MSRB3, PKP4, RSRC1 |
About the gene
| Synonyms | LASS6 |
|---|---|
| Chromosome | 2: 168456249-168775134 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Predicted membrane proteins |
| Molecular function | Transferase |
| Biological process | Inflammatory response, Lipid biosynthesis, Lipid metabolism |
Function
Ceramide synthase that catalyzes the transfer of the acyl chain from acyl-CoA to a sphingoid base, with high selectivity toward palmitoyl-CoA (hexadecanoyl-CoA; C16:0-CoA). Can use other acyl donors, but with less efficiency (By similarity). N- acylates sphinganine and sphingosine bases to form dihydroceramides and ceramides in de novo synthesis and salvage pathways, respectively. Ceramides generated by CERS6 play a role in inflammatory response (By similarity). Acts as a regulator of metabolism and hepatic lipid accumulation (By similarity). Under high fat diet, palmitoyl- (C16:0-) ceramides generated by CERS6 specifically bind the mitochondrial fission factor MFF, thereby promoting mitochondrial fragmentation and contributing to the development of obesity (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.