RAP2A — RAP2A, member of RAS oncogene family
RAP2A belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
RAP2A's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | TCR Activation Signaling TCR/AP1/NFKb pathway | AKNA, ATP6V1A, BCL2L11, KIF20B, LAX1, NAA50, NEDD9, NPC1 +6 more | View in SCUBA |
| Fibroblasts | Pericyte-like Fibroblast Migration & adhesion | CDK6, CHL1, DSEL, EHD2, ENTPD1, HEPH, ITGB3, NID1 +7 more | View in SCUBA |
| Smooth muscle cells | Notch-TGFbeta Signaling Development | ACKR3, AFAP1L2, CSRNP3, GJC1, HTR1F, JAG1, LRRC10B, SLC38A11 +3 more | View in SCUBA |
About the gene
| Synonyms | K-REV, RAP2 |
|---|---|
| Chromosome | 13: 97434169-97469128 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Predicted intracellular proteins |
| Molecular function | Hydrolase |
Function
Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. In its active form interacts with and regulates several effectors including MAP4K4, MINK1 and TNIK. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it is part of several signaling cascades and regulates cytoskeletal rearrangements, cell migration, cell adhesion and cell spreading.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.