RELCH — RAB11 binding and LisH domain, coiled-coil and HEAT repeat containing
RELCH belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
RELCH's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Macrophages | Rho GTPase Signaling Cytoskeletal | ABHD18, AFF1, ARHGEF7, DIP2B, DNAAF9, DOCK11, EVI5, GNAQ +24 more | View in SCUBA |
| Mucosal-associated invariant T cell | Histone Modification DNA/chromatin regulation | ANKRD17, ARHGEF6, ASH1L, CLTC, FAM120B, KDM4C, NRDC, PCM1 +3 more |
About the gene
| Synonyms | FLJ33841, HsT3308, HsT885, KIAA1468 |
|---|---|
| Chromosome | 18: 62187255-62310249 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins |
| Biological process | Lipid transport, Transport |
Function
Regulates intracellular cholesterol distribution from recycling endosomes to the trans-Golgi network through interactions with RAB11 and OSBP. Functions in membrane tethering and promotes OSBP-mediated cholesterol transfer between RAB11-bound recycling endosomes and OSBP-bound Golgi-like membranes
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.