Histone Modification
Gene co-expression module in Mucosal-associated invariant T cell
| Category | DNA/chromatin regulation |
|---|---|
| Genes | 12 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 12 genes have a known function matching the annotation |
Why this annotation
ASH1L is a histone H3K36 methyltransferase; KDM4C is a histone H3K9/K36 demethylase — together they form a histone modification axis. FAM120B is an RNA-binding protein with chromatin association. ARHGEF6 is a Rac/Cdc42 guanine nucleotide exchange factor expressed in T cells and linked to immune synapse formation. CLTC (clathrin heavy chain) and VPS13C participate in endosomal/vesicle trafficking and autophagy. SPG11 regulates autophagosome maturation. PCM1 is a pericentriolar material component. SF3B3 is a splicing factor subunit. Core coherence is high, suggesting a tight co-regulatory program combining histone modification with vesicle/membrane trafficking.
Genes
ANKRD17, ARHGEF6, ASH1L, CLTC, FAM120B, KDM4C, NRDC, PCM1, RELCH, SF3B3, SPG11, VPS13C
Most correlated modules
- Epigenetic Maintenance · correlation 0.91
- Lymphocyte Survival · correlation 0.90
- Chromatin Remodeling · correlation 0.90
- TGF-β Immune Regulation · correlation 0.87
- Lymphocyte Migration · correlation 0.86
- Chromatin Epigenetic Regulation · correlation 0.86
- RNA Splicing Processing · correlation 0.84
- Vesicle Membrane Trafficking · correlation 0.84
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.