Rho GTPase Signaling
Gene co-expression module in Macrophages
| Category | Cytoskeletal |
|---|---|
| Genes | 33 |
| Annotation certainty | 1 of 5 |
| Annotation consistency | 8 of 33 genes have a known function matching the annotation |
Why this annotation
Hub genes include LPP (focal adhesion LIM protein), MYO9A (unconventional myosin with RhoGAP domain), DOCK11 (Rho GEF for Cdc42/Rac), ARHGEF7 (Rho GEF), GNAQ (Gq signaling), STIM1 (store-operated calcium entry), and RELCH (Rab11-FIP3 vesicle trafficking). The dominant theme across top-ranked genes is Rho GTPase-mediated cytoskeletal regulation and actin dynamics. Weak coherence and all-weak memberships indicate a loosely defined module, but the cytoskeletal/Rho GTPase signal is the most consistent thread. Slight enrichment in mono_mac subset for several genes is consistent with monocyte-derived macrophage cytoskeletal activity.
Genes
ABHD18, AFF1, ARHGEF7, DIP2B, DNAAF9, DOCK11, EVI5, GNAQ, IL1RAP, LPP, MED13L, MLLT10, MYO9A, NCOA1, NLK, PIP5K1A, PLD1, PPP3CA, PSME4, RABGAP1, RANBP9, RELCH, RNF216, SNX29, SPPL3, STIM1, TENT2, TSC22D2, USP24, WDFY3, WDR7, WWP2, YTHDF3
Most correlated modules
- MITF Lysosomal Program · correlation 0.98
- DNA Damage Response · correlation 0.98
- Transcriptional Regulation · correlation 0.98
- Ubiquitin Proteasome Regulation · correlation 0.98
- Rho GTPase Signaling · correlation 0.97
- Endosomal Vesicle Trafficking · correlation 0.97
- Golgi Vesicle Trafficking · correlation 0.96
- Chromatin Remodeling · correlation 0.96
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.