PCM1 — Pericentriolar material 1
PCM1 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PCM1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Post-transcriptional regulation RNA processing | BCL11B, CCDC14, CHD2, CHD6, CREBZF, DDX39B, DNASE1, EVI2B +21 more | View in SCUBA |
| Gamma-delta T cells | DNA Damage Response DNA/chromatin regulation | AP1B1, CCAR1, CHD8, DOCK2, EP400, ERBIN, GOLM2, IPO8 +17 more | |
| Innate lymphoid cells | Centrosome & Scaffolding Cytoskeleton & motility | AKAP9, APPL1, ARID4A, CCDC91, CPNE3, ETNK1, FAM204A, GOPC +14 more | View in SCUBA |
| Macrophages | RNA Processing Housekeeping Housekeeping | BAZ1A, BDP1, CCAR1, CCDC88A, CLIP1, CUL5, DHX36, DNM1L +32 more | View in SCUBA |
| Mucosal-associated invariant T cell | Histone Modification DNA/chromatin regulation | ANKRD17, ARHGEF6, ASH1L, CLTC, FAM120B, KDM4C, NRDC, RELCH +3 more |
About the gene
| Synonyms | PTC4 |
|---|---|
| Chromosome | 8: 17922842-18029948 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Disease related genes, Predicted intracellular proteins |
| Biological process | Cilium biogenesis/degradation |
Function
Required for centrosome assembly and function. Essential for the correct localization of several centrosomal proteins including CEP250, CETN3, PCNT and NEK2. Required to anchor microtubules to the centrosome. Also involved in cilium biogenesis by recruiting the BBSome, a ciliary protein complex involved in cilium biogenesis, to the centriolar satellites. Recruits the tubulin polyglutamylase complex (TPGC) to centriolar satellites.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.