SCAF4 — SR-related CTD associated factor 4
SCAF4 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SCAF4's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | T Cell Maturation T cell maturation | CDK13, CWF19L2, EMB, EZH1, ICE1, IKZF1, JAK1, KLF13 +16 more | |
| Macrophages | ER Stress Response Stress | ARHGEF12, ATXN7, BTBD7, CD2AP, CLIP2, DAPK1, DST, ERN1 +14 more | View in SCUBA |
About the gene
| Synonyms | DKFZp434E098, KIAA1172, SFRS15, SRA4 |
|---|---|
| Chromosome | 21: 31671000-31732118 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Plasma proteins, Predicted intracellular proteins |
| Molecular function | RNA-binding |
| Biological process | Transcription, Transcription regulation |
Function
Anti-terminator protein required to prevent early mRNA termination during transcription. Together with SCAF8, acts by suppressing the use of early, alternative poly(A) sites, thereby preventing the accumulation of non-functional truncated proteins. Mechanistically, associates with the phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit (POLR2A), and subsequently binds nascent RNA upstream of early polyadenylation sites to prevent premature mRNA transcript cleavage and polyadenylation. Independently of SCAF8, also acts as a suppressor of transcriptional readthrough
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.