SH3PXD2A — SH3 and PX domains 2A
SH3PXD2A belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SH3PXD2A's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Glial cells | Peripheral Glial Myelination Myelination | FAM210B, FRMD6, GNAS, KDSR, MAF, MYL9, OLFML2A, OLFML3 +7 more | View in SCUBA |
| Smooth muscle cells | ER Secretory Trafficking Protein processing & ER | ARF4, DEGS1, GYPC, P4HB, PDIA6, SSR3, TMED9, TMEM123 | View in SCUBA |
About the gene
| Synonyms | FISH, KIAA0418, SH3MD1 |
|---|---|
| Chromosome | 10: 103594027-103855584 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
Function
Adapter protein involved in invadopodia and podosome formation, extracellular matrix degradation and invasiveness of some cancer cells. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. In association with ADAM12, mediates the neurotoxic effect of amyloid-beta peptide.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.