ER Secretory Trafficking
Gene co-expression module in Smooth muscle cells
| Category | Protein processing & ER |
|---|---|
| Genes | 9 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 7 of 9 genes have a known function matching the annotation |
Why this annotation
Tight ER/early secretory pathway module: protein disulfide isomerases (PDIA6, P4HB), signal-sequence receptor subunit SSR3 (translocon-associated), COPI/COPII cargo machinery (TMED9, ARF4), and DEGS1 (ER lipid/sphingolipid enzyme). Essentially the same program as M107 but without the chaperone/cytokine-driver component — a housekeeping ER-trafficking axis supporting collagen/ECM secretion.
Genes
ARF4, DEGS1, GYPC, P4HB, PDIA6, SH3PXD2A, SSR3, TMED9, TMEM123
Most correlated modules
- ER Chaperone/UPR · correlation 0.86
- Basal metabolic housekeeping · correlation 0.77
- Translocon & Proteostasis · correlation 0.77
- Activated Myofibroblast · correlation 0.74
- Mesenchymal Adhesion Program · correlation 0.73
- Redox-Metabolic Housekeeping · correlation 0.72
- Membrane Protein Turnover · correlation 0.72
- hnRNP & Proteasome · correlation 0.69
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.