SHOC2 — SHOC2 leucine rich repeat scaffold protein
SHOC2 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SHOC2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Vesicle trafficking Housekeeping | AP2A1, APPL2, ARHGAP35, ATAD2, DHX30, DYRK1B, ERP44, FAM91A1 +21 more | View in SCUBA |
| Macrophages | RAS-MAPK Signaling Housekeeping | ARF4, ATG12, CAMTA1, CDC37, CHMP4B, ETFA, GLA, HMGA1 +26 more | View in SCUBA |
About the gene
| Synonyms | KIAA0862, SOC-2, SOC2, SUR-8, SUR8 |
|---|---|
| Chromosome | 10: 110919367-111017307 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins, RAS pathway related proteins |
Function
Core component of the SHOC2-MRAS-PP1c (SMP) holophosphatase complex that regulates activation of the MAPK pathway. Acts as a scaffolding protein in the SMP complex. The SMP complex specifically dephosphorylates the inhibitory phosphorylation at 'Ser-259' of RAF1 kinase, 'Ser-365' of BRAF kinase and 'Ser-214' of ARAF kinase, stimulating their kinase activities. The SMP complex enhances the dephosphorylation activity and substrate specificity of PP1c.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.