SLA2 — Src like adaptor 2
SLA2 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SLA2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Vesicular trafficking Housekeeping | ACSL4, ARL8B, BLOC1S2, C3orf38, DTX3L, EFCAB14, GGA2, HMGXB3 +17 more | View in SCUBA |
| Gamma-delta T cells | TCR Threshold Regulation TCR Signaling | AGO2, ATP8A1, AUTS2, CMIP, CNOT6L, CSNK1D, FOXO1, GSPT1 +8 more | |
| Natural Killer cells | NK Cytotoxic Signaling Cytotoxicity | BCL2L11, CBLB, CRYBG1, DAZAP2, FYN, GPATCH8, HNRNPUL1, MAPK1 +3 more | View in SCUBA |
About the gene
| Synonyms | C20orf156, FLJ21992, SLAP-2 |
|---|---|
| Chromosome | 20: 36612318-36646196 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Plasma proteins, Predicted intracellular proteins |
Function
Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. May act by linking signaling proteins such as ZAP70 with CBL, leading to a CBL dependent degradation of signaling proteins
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.