HNRNPUL1 — Heterogeneous nuclear ribonucleoprotein U like 1
HNRNPUL1 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
HNRNPUL1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Effector activation NFkB TCR/AP1/NFKb pathway | ADAM19, AHR, ARFGAP3, ATF5, BHLHE40, CGAS, DUSP5, ETF1 +23 more | View in SCUBA |
| Innate lymphoid cells | Inflammasome Activation Inflammation | ANKRD28, AP3D1, ARHGEF7, CCNH, CD55, CDC42SE1, CHD7, CHKA +19 more | View in SCUBA |
| Macrophages | General Cellular Maintenance Housekeeping | ABHD13, AKT2, AMD1, C1GALT1, DCUN1D1, FBXL3, FMR1, GAK +13 more | View in SCUBA |
| Mucosal-associated invariant T cell | Stress Granule Response Stress | BZW1, CRTC2, EZR, G3BP2, HERPUD2, MAP3K8, MAPK1IP1L, RNF138 +3 more | |
| Natural Killer cells | NK Cytotoxic Signaling Cytotoxicity | BCL2L11, CBLB, CRYBG1, DAZAP2, FYN, GPATCH8, MAPK1, RAPGEF1 +3 more | View in SCUBA |
About the gene
| Synonyms | E1B-AP5, E1BAP5, FLJ12944, HNRPUL1 |
|---|---|
| Chromosome | 19: 41262496-41307787 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Plasma proteins, Predicted intracellular proteins |
| Molecular function | Activator, Repressor, Ribonucleoprotein, RNA-binding |
| Biological process | Transcription, Transcription regulation |
Function
Acts as a basic transcriptional regulator. Represses basic transcription driven by several virus and cellular promoters. When associated with BRD7, activates transcription of glucocorticoid- responsive promoter in the absence of ligand-stimulation. Also plays a role in mRNA processing and transport. Binds avidly to poly(G) and poly(C) RNA homopolymers in vitro.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.