TCR Threshold Regulation
Gene co-expression module in Gamma-delta T cells
| Category | TCR Signaling |
|---|---|
| Genes | 17 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 17 genes have a known function matching the annotation |
Why this annotation
Key hub genes include RUNX3 (T cell tissue residency/differentiation TF), FOXO1 (naive/memory T cell transcription factor), CBLB (E3 ubiquitin ligase, negative regulator of TCR), MAP3K8/TPL2 (TCR-to-NF-κB/MAPK kinase), PIK3R1 (PI3K p85 regulatory subunit), SLA2 (Src-like adaptor, TCR regulation), and AGO2 (miRNA-mediated gene silencing). CMIP modulates c-Maf and T cell activation. Together these define a T cell homeostasis and activation-threshold regulation program balancing quiescence and TCR responsiveness.
Genes
AGO2, ATP8A1, AUTS2, CMIP, CNOT6L, CSNK1D, FOXO1, GSPT1, MAP3K8, PDZD8, PIK3R1, RUNX3, SDCBP, SLA2, SLC5A6, SUPV3L1, SURF4
Most correlated modules
- Chromatin Epigenetic Regulation · correlation 0.93
- cAMP Lipid Signaling · correlation 0.87
- Ubiquitin-p53 Regulation · correlation 0.86
- TCR Inhibitory Signaling · correlation 0.86
- ER Stress Response · correlation 0.84
- NF-κB Activation · correlation 0.84
- Pre-mRNA Splicing · correlation 0.83
- DNA Damage Ubiquitin · correlation 0.83
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.