SMPDL3A — Sphingomyelin phosphodiesterase acid like 3A
SMPDL3A belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SMPDL3A's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Tfh IL21 help B cell help | APBB2, CDYL2, GDF7, HIF1A, IL21, KIAA1671, MFHAS1, MYB +6 more | View in SCUBA |
| Enterocytes | ER-autophagy homeostasis Protein processing & ER | AQP11, CCSER2, CTSD, MFSD2A, PLOD2, RB1CC1, REEP3, RESF1 +1 more | View in SCUBA |
About the gene
| Synonyms | ASM3A, ASML3a, FLJ20177, yR36GH4.1 |
|---|---|
| Chromosome | 6: 122789049-122809720 |
| Predicted location | Intracellular, Secreted |
| Essential gene | No |
| Protein class | Predicted intracellular proteins, Predicted secreted proteins |
| Molecular function | Hydrolase |
Function
Cyclic-nucleotide phosphodiesterase that acts as a negative regulator of innate immunity by mediating degradation of 2',3'-cGAMP, thereby inhibiting the cGAS-STING signaling. Specifically linearizes 2',3'-cGAMP into 2'5'-bond pGpA and further hydrolyzes pGpA to produce GpA. Also has in vitro nucleotide phosphodiesterase activity with nucleoside triphosphates, such as ATP. Has in vitro activity with p-nitrophenyl-TMP. Has lower activity with nucleoside diphosphates, and no activity with nucleoside monophosphates. Has in vitro activity with CDP-choline, giving rise to CMP and phosphocholine. Has in vitro activity with CDP-ethanolamine. Does not have sphingomyelin phosphodiesterase activity.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.