RESF1 — Retroelement silencing factor 1
RESF1 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
RESF1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Enterocytes | ER-autophagy homeostasis Protein processing & ER | AQP11, CCSER2, CTSD, MFSD2A, PLOD2, RB1CC1, REEP3, SMPDL3A +1 more | View in SCUBA |
| Gamma-delta T cells | Interferon Antiviral Response Inflammation | ANKRD44, DDX17, DDX60L, IARS2, KIAA0319L, KRBOX5, LZIC, MIA2 +14 more | |
| Innate lymphoid cells | ILC3 identity Differentiation | ABCC1, BCL6, CCND3, CELF2, CHKB, DNAAF2, ENSG00000285976, EREG +31 more | View in SCUBA |
| Macrophages | Macrophage Endocytic Signaling Lysosomal & pahgocytosis | APLP2, ARHGAP30, ARHGEF2, ATF6B, BAG6, CLSTN1, CMTR2, CTBS +20 more | View in SCUBA |
| Mucosal-associated invariant T cell | Chromatin Epigenetic Regulation DNA/chromatin regulation | ACAP2, APBB1IP, ARHGAP25, ATM, CD247, CHD9, CLCN3, DDX17 +14 more |
About the gene
| Synonyms | C12orf35, FLJ10652, FLJ20696, GET, KIAA1551, UTA2-1 |
|---|---|
| Chromosome | 12: 31959370-31993107 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
Function
Plays a role in the regulation of imprinted gene expression, regulates repressive epigenetic modifications associated with SETDB1. Required for the recruitment or accumulation of SETDB1 to the endogenous retroviruses (ERVs) and maintenance of repressive chromatin configuration, contributing to a subset of the SETDB1-dependent ERV silencing in embryonic stem cells
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.