PLOD2 — Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2
PLOD2 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PLOD2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Enterocytes | ER-autophagy homeostasis Protein processing & ER | AQP11, CCSER2, CTSD, MFSD2A, RB1CC1, REEP3, RESF1, SMPDL3A +1 more | View in SCUBA |
| Pericytes | Fibrotic ECM Remodeling ECM remodeling | BGN, CYGB, LAMC3, LGALS3BP, LPL, MMP11, NREP, PCDH18 +2 more | View in SCUBA |
| Smooth muscle cells | Lysosomal-secretory processing Protein processing & ER | BZW2, COPZ1, CTSL, LAMP1, PIGT, PRMT2, RGS9, RPN2 +5 more | View in SCUBA |
About the gene
| Synonyms | LH2, TLH |
|---|---|
| Chromosome | 3: 146035139-146163725 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Dioxygenase, Oxidoreductase |
Function
Forms hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens. These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.