RB1CC1 — RB1 inducible coiled-coil 1
RB1CC1 belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
RB1CC1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Transcription/RNA processing RNA processing | ANKRD17, BDP1, CCDC97, CDK13, CHIC2, CLK4, CNOT6L, CRNKL1 +29 more | View in SCUBA |
| Enterocytes | ER-autophagy homeostasis Protein processing & ER | AQP11, CCSER2, CTSD, MFSD2A, PLOD2, REEP3, RESF1, SMPDL3A +1 more | View in SCUBA |
| Gamma-delta T cells | T Cell Exhaustion Exhaustion | ACADVL, ACSS1, ADSS2, B4GALT3, CDK11A, CHP1, CNOT2, CNOT8 +20 more | |
| Lymphatic endothelial | Basement Membrane ECM migration & adhesion | BRD4, COL4A1, COL4A2, GOLGA4, ITGAV, PITPNB, PXDN, RAI14 +4 more | View in SCUBA |
| Macrophages | mRNA Splicing Processing Housekeeping | ACIN1, ARID3A, BOD1L1, CCNL2, CDK12, CLK4, DCP2, GPATCH2L +20 more | View in SCUBA |
| Mucosal-associated invariant T cell | Transcriptional Repression Immune regulation | ANKRD11, CMIP, MXI1, NR3C1, PELI2, PROSER1, RCOR1, RFTN1 +7 more | |
| Neutrophils | Ubiquitin-Proteasome Turnover Housekeeping | BLTP3B, CACUL1, CLIP1, FBXL20, FBXO33, FGD3, IL18RAP, KIF13A +10 more |
About the gene
| Synonyms | ATG17, Cc1, DRAGOU14, FIP200, KIAA0203, PPP1R131 |
|---|---|
| Chromosome | 8: 52622458-52745843 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Human disease related genes, Predicted intracellular proteins |
| Biological process | Autophagy, Cell cycle, Transcription, Transcription regulation |
Function
Involved in autophagy. Regulates early events but also late events of autophagosome formation through direct interaction with Atg16L1. Required for the formation of the autophagosome-like double-membrane structure that surrounds the Salmonella-containing vacuole (SCV) during S.typhimurium infection and subsequent xenophagy (By similarity). Involved in repair of DNA damage caused by ionizing radiation, which subsequently improves cell survival by decreasing apoptosis (By similarity). Inhibits PTK2/FAK1 and PTK2B/PYK2 kinase activity, affecting their downstream signaling pathways. Plays a role as a modulator of TGF-beta-signaling by restricting substrate specificity of RNF111 (By similarity). Functions as a DNA-binding transcription factor. Is a potent regulator of the RB1 pathway through induction of RB1 expression. Plays a crucial role in muscular differentiation. Plays an indispensable role in fetal hematopoiesis and in the regulation of neuronal homeostasis (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.