SNAP29 — Synaptosome associated protein 29
SNAP29 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SNAP29's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Vesicle trafficking Housekeeping | AP2A1, APPL2, ARHGAP35, ATAD2, DHX30, DYRK1B, ERP44, FAM91A1 +21 more | View in SCUBA |
| Innate lymphoid cells | Transcription RNA Processing RNA processing & translation | ARMCX6, BANF1, CCAR1, CLDND1, COMMD1, FEZ2, HELZ, HSBP1 +11 more | View in SCUBA |
| Macrophages | Efferocytosis Anti-inflammatory Lysosomal & pahgocytosis | ABHD12, ADGRG5, AIG1, AXL, CCS, CD101, CD1D, CD300A +18 more | View in SCUBA |
About the gene
| Synonyms | CEDNIK, SNAP-29 |
|---|---|
| Chromosome | 22: 20859007-20891214 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Predicted intracellular proteins |
| Biological process | Autophagy, Cilium biogenesis/degradation, Protein transport, Transport |
Function
SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. SNAP29 is a SNARE involved in autophagy through the direct control of autophagosome membrane fusion with the lysososome membrane. Also plays a role in ciliogenesis by regulating membrane fusions.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.