Arterial EC Identity
Gene co-expression module in Endothelial
| Category | Endothelial cell development |
|---|---|
| Genes | 11 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 5 of 11 genes have a known function matching the annotation |
Why this annotation
Top hub TLE1 is a Groucho-family Wnt/Notch co-repressor implicated in arterial EC specification. FABP4 is a well-established marker of arterial and capillary ECs. MDK (midkine) is a heparin-binding growth factor expressed in vascular development. MAP3K1 participates in VEGF/MAPK signaling. RASSF4 is a Ras effector. SNCAIP (synphilin-1) and PCBD1 are less clearly vascular. The module shows minimal disease association, consistent with a constitutive EC identity program. In the context of neighboring lymphatic/venous modules, this likely represents an arterial or capillary EC identity state.
Genes
CCDC71L, FABP4, LAPTM5, MAP3K1, MDK, PCBD1, PMVK, RASSF4, SCNN1B, SNCAIP, TLE1
Most correlated modules
- YAP Mechanotransduction · correlation 0.85
- Actomyosin Contractility · correlation 0.81
- Venous EC Identity · correlation 0.74
- NF-κB Stress Signaling · correlation 0.69
- Inflammatory Angiogenesis · correlation 0.68
- Inflammatory ECM Remodeling · correlation 0.66
- EC Cytoskeletal Scaffold · correlation 0.64
- Arterial EC Homeostasis · correlation 0.63
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.