SOX13 — SRY-box transcription factor 13
SOX13 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SOX13's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | EC Inflammatory Activation Inflammation | ARHGAP4, ARHGEF2, ARL15, ATP13A3, CAPZA2, CD58, GFOD1, GJA4 +12 more | View in SCUBA |
| Gamma-delta T cells | γδ T Cell Identity T cell maturation | AGAP1, AGPAT4, C1orf21, CD226, CD47, GAS7, ITGA5, ITGAM +7 more |
About the gene
| Synonyms | ICA12, MGC117216, Sox-13 |
|---|---|
| Chromosome | 1: 204073115-204127743 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Plasma proteins, Predicted intracellular proteins, Transcription factors |
| Molecular function | DNA-binding, Repressor |
| Biological process | Differentiation, Transcription, Transcription regulation |
Function
Transcription factor that binds to DNA at the consensus sequence 5'-AACAAT-3'. Binds to the proximal promoter region of the myelin protein MPZ gene, and may thereby be involved in the differentiation of oligodendroglia in the developing spinal tube (By similarity). Binds to the gene promoter of MBP and acts as a transcriptional repressor (By similarity). Binds to and modifies the activity of TCF7/TCF1, thereby inhibiting transcription and modulates normal gamma-delta T-cell development and differentiation of IL17A expressing gamma-delta T-cells (By similarity). Regulates expression of BLK in the differentiation of IL17A expressing gamma-delta T-cells (By similarity). Promotes brown adipocyte differentiation (By similarity). Inhibitor of WNT signaling.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.