γδ T Cell Identity
Gene co-expression module in Gamma-delta T cells
| Category | T cell maturation |
|---|---|
| Genes | 16 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 11 of 16 genes have a known function matching the annotation |
Why this annotation
Hub genes include ITGAM (integrin αM/CD11b), ITGA5 (integrin α5), VCL (vinculin), MYO1G (myosin), NHSL2, PLEKHG3 (RhoGEF), and GAS7 — all cytoskeletal/adhesion components. SOX13 is a defining transcription factor for γδ T cells. CD226 (DNAM-1) is an activating receptor enriched on γδ/NK cells. AGAP1 regulates Arf GTPases at focal contacts. The module uniformly expressed across subsets reflects a basal γδ T cell identity program coupled with integrin-mediated adhesion and cytoskeletal organization.
Genes
AGAP1, AGPAT4, C1orf21, CD226, CD47, GAS7, ITGA5, ITGAM, MYO1G, NHSL2, PLEKHG3, SBK1, SOX13, STK38, TSPAN14, VCL
Most correlated modules
- TCR Proximal Signaling · correlation 0.92
- TGF-β Migration Program · correlation 0.90
- Effector Cell Migration · correlation 0.87
- TCR-Cytokine Signaling · correlation 0.87
- Coinhibitory Checkpoint · correlation 0.85
- Cytotoxic Effector Program · correlation 0.84
- Cytotoxic Effector Program · correlation 0.83
- Butyrophilin gd Activation · correlation 0.82
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.