Notch TGF-β Endothelial
Gene co-expression module in Lymphatic endothelial
| Category | endothelial development |
|---|---|
| Genes | 20 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 20 genes have a known function matching the annotation |
Why this annotation
SOX7 (endothelial/vascular SOX TF), HEY1 (Notch target, arteriovenous specification), SMAD7 (TGF-β/BMP inhibitory SMAD), SKIL (SnoN, TGF-β/SMAD transcriptional repressor), and ARL4C (ARF GTPase, cytoskeletal remodeling) define a vascular/endothelial developmental program with TGF-β and Notch pathway regulation. WEE1 and CCNL1 add cell cycle checkpoint context. The significant delta_inflammation_CD (0.897 sig.) may reflect inflammatory remodeling of lymphatic endothelial identity. As a neighbor to the NF-κB and stress modules, this module may represent a developmental/identity program modulated by inflammation in intestinal lymphatics.
Genes
ARF6, ARL4C, C16orf87, CCNL1, CLK1, DEDD2, ELOC, GPBP1, HEY1, LGALSL, NXT1, SAMD1, SKIL, SLC25A33, SMAD7, SOX7, TMEM70, TSPYL2, WEE1, ZBTB2
Most correlated modules
- Integrated Stress Response · correlation 0.88
- NF-κB Negative Feedback · correlation 0.86
- Heat Shock Chaperone · correlation 0.84
- DNA Damage Autophagy · correlation 0.84
- Hypoxic Stress Response · correlation 0.84
- NF-κB Inflammatory Activation · correlation 0.79
- Heat Shock Response · correlation 0.77
- Stress Granule Assembly · correlation 0.73
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.